Montague Road passes through the western side of the town of Leverett, crossing the New England Central Railroad tracks before entering Sunderland for a short distance, crossing the tracks again before entering Montague.

It meets the northern end of Route 47 south of Montague Center before passing Lake Pleasant and crossing the tracks twice more before crossing the Millers River at Millers Falls, entering the town of Erving.

It joins Route 10 (just east of Bennett's Meadow Bridge over the Connecticut River) for just under 2.5 miles (4.0 km), before splitting just south of the New Hampshire state line.

It shortly turns northwestward before entering the town of Hinsdale and becoming New Hampshire Route 63.

There it turned north onto its present alignment, ending at Route 10 in Northfield.