Massacre Mania was the third and final film directed by Paolo Bianchini for producer Gabriele Crisanti, following The Devil's Man and Superargo and the Faceless Giants.

[2] Woods described the script as improvized, stating that "these were nearly always collaborative efforts (where almost everyone involved had input).

"[2] Woods spoke positively about working on the film, specifically on how it was a departure from the Westerns and that he "loved the comic book implications" of Massacre Mania.

"[4] Curti felt the film was a "strange mixture of science fiction, thriller and comic-book style adventure"[2] Massacre Mania was submitted to the Italian board of censors in October 1967, one month after Superargo and the Faceless Giants, but was eventually released earlier than that film.

[4] The Italian title for the film is Hipnos follia di massacro and is sometimes misspelled as Hypnos in reference books.