[2] With the fall and the end of the Letta government at the behest of the new Democratic Party's secretary Matteo Renzi to become Prime Minister, and at the birth of his government, on 28 February 2014 he was appointed undersecretary of state at the Ministry of Labor and Social Policies, alongside the minister Giuliano Poletti.
On 21 July 2017 he announced his resignation from the post of undersecretary at the Ministry of Labour, to then return to Forza Italia on the following 25 July.At the same time, he founded the Popular Apulia movement, in the orbit of the centre-right coalition.
[3] In the 2018 Italian general election, he was a candidate in the single-member constituency Bari-Bitonto for the Chamber of Deputies, supported by the centre-right coalition of Forza Italia, but was not re-elected.
In the 2019 European elections in Italy Cassano reached an agreement with Bruno Tabacci, national president of More Europe, to include a candidate from Popular Apulia in the party lists for the southern district.
[6] In view of the 2022 Italian general election, Cassano joined Action, a party led by Carlo Calenda allied with Italia Viva.
On 19 October, the regional council of Apulia voted for Cassano to be dismissed from his role as manager of ARPAL.