The second season of the American television drama series Masters of Sex premiered on July 13, 2014, and concluded on September 28, 2014.

Showtime broadcast the twelve episode second season on Sundays at 10:00 pm (ET) in the United States.

[7] Several new recurring roles were cast for the second season, including Betsy Brandt and Keke Palmer in March 2014,[8][9] Sarah Silverman in April,[10] René Auberjonois, Christian Borle, and Courtney B. Vance in May,[11][12] and Erin Cummings in June.

"[27] Hank Stuever of The Washington Post wrote "It is intelligent, witty, quick-paced and surprising; it is tragic without being emotionally devastating.

[29] For the 5th Critics' Choice Television Awards, Julianne Nicholson was nominated for Best Guest Performer in a Drama Series.