The municipality has an area of 1,003.7 km² (387.53 sq mi), which includes many small outlying communities, the largest of which is the town of San Antonio del Coyote.

In 1839, a group of settlers settled in "la Vega de Marrufo", property of the marquisate of Aguayo, however it was abandoned some time later due to major floods.

According to the census carried out by the National Institute of Statistics and Geography (INEGI), Matamoros has a total of 59,762 inhabitants, 29,256 men and 30,506 women.4 The average level of schooling is 9.73 years.

On July 4 of each year, the fair of La Virgen del Refugio, patron saint of the city, is organized, which includes mechanical games, grape harvests and religious music concerts.

Among the most visited places are the Plaza de Armas, the Tobacco Cave, Home Run, the main church, the Historic Center and the Municipal Gymnasium.