Matelea floridana (also called Florida milkvine or Florida spiny pod) is a flowering plant within the Milkweed Subfamily (Family Apocynaceae; Subfamily Asclepiadoideae).

[1] It is endemic to Florida and two counties in Georgia, and is listed as Endangered.

[4] Leaf pairs are opposite, cordate from 5–10 (2–4 in) cm in length, lightly pubescent.

It is slow to grow, but after around 60 days, the plant can then be trained to climb.

Once plant has established upon a vertical face, flowers may begin to form at nearly every node.