Materdomini is an Italian hamlet (frazione) situated in the municipality of Caposele, Province of Avellino, Campania.

On October 16, 1755, Gerard Majella (originally of Muro Lucano) died in this chapel and was buried there.

Mainly for this reason, during the first half of the 20th century, it grew into a village in the neighborhood of the Basilica of San Gerardo Maiella, one of the most important and respected Catholic sanctuaries [2] of Campania and the surrounding areas.

It is two km from Caposele, five from Teora, seven from Lioni, nine from Laviano (in the Province of Salerno).

The exit "Caposele" of the rapid road Lioni-Contursi serves Materdomini directly.