[citation needed] After her father's death in 85, Matidia along with her half-sisters lived with their grandmother and mother and were raised in the household of Trajan, his wife Plotina and her stepfather.

Her husband or children, if they ever existed, did not register in historical records, and she remained single for the rest of her life (which was unusual at the time).

[1] Excavations in the area of Sessa Aurunca showed that Matidia was a major benefactress in the city, attesting her wealth, culture and influence.

Matidia underwrote the restoration of the theatre of Sessa Aurunca which was probably damaged by an earthquake during the rule of emperor Antoninus Pius (138-161).

From her will, various family members and associates received a million sesterces (an ancient Roman unit of currency), her estate, and various other items she had.