He is a founding member of the punk band Link 80 and co-creator of the filmmaking collectives Chad, Matt & Rob and Radio Silence.

On the band's first two albums, 17 Reasons and Killing Katie, Bettinelli-Olpin played guitar, sang backing vocals and co-wrote the lyrics with singer Nick Traina.

[2][3] After leaving Link 80, Bettinelli-Olpin worked as a music journalist and interviewed bands including Alkaline Trio, Dropkick Murphy's, Lawrence Arms, Avail, Blur, Violent Femmes, the Breeders, the Mars Volta and the Psychedelic Furs.

While working in the mailroom at New Line Cinema, he formed the filmmaking collective Chad, Matt & Rob in 2007 and Radio Silence in 2011.

[15] Among their numerous short films is the viral found footage style video Roommate Alien Prank Gone Bad and five installments of their first-of-its-kind series of Interactive Adventures.

In March 2020, it was announced that Bettinelli-Olpin would co-direct the fifth installment of the Scream franchise, alongside Tyler Gillett, with Kevin Williamson serving as executive producer.

[37][38][39][40][41] In all of their films, Bettinelli-Olpin and Gillett have used music from Asian Man Records artists including Alkaline Trio, Link 80, MU330 and Laura Stevenson and the Cans as well as music from the Bay Area including Too Short, The Atom Age, Link 80, The Jacka, Kamaiyah and P-Lo.