He has served as the quarterback coach of the Washington Redskins, Notre Dame, and the Atlanta Falcons and the offensive coordinator for the Los Angeles Rams and the Tennessee Titans.

He transferred to Saginaw Valley State in Division II, and he played quarterback from 2000 to 2002, guiding the Cardinals to the D-II playoffs each season.

[3] During his three-year run as the Cardinal quarterback, SVSU compiled a record of 29–8 overall and qualified for the NCAA Division II Playoffs each year.

[4] LaFleur briefly played professionally in the National Indoor Football League with the Omaha Beef as the backup quarterback in 2003 and, the following summer, signed with the Billings Outlaws.

He assisted both wide receivers and quarterbacks during his two-year stint there and developed a close relationship with offensive coordinator Kyle Shanahan.

[9] From 2011 to 2013, LaFleur worked alongside 4 other future head coaches in Washington; Kyle Shanahan, Sean McVay, Mike McDaniel, and Raheem Morris.

The Falcons reached Super Bowl LI, where they faced the New England Patriots, but squandered a 28–3 lead and lost 34–28 in overtime, a monumental meltdown that drew heavy fan and media criticism.

[16] Joining new head coach Mike Vrabel, LaFleur's role in directing the offense increased, as he had play-calling responsibilities unlike during his tenure with the Rams.

[25] Despite this, the Packers continued rolling, and LaFleur clinched his second consecutive NFC North title and playoff berth in Week 14 with a 31–24 victory against the Detroit Lions.

With a 35–16 win over the Chicago Bears in Week 17, Green Bay clinched the NFC's number one seed and home-field advantage throughout the playoffs for the first time since the 2011 season.

His team finished as the league's number one offense, scoring 509 points over the course of the season, and with quarterback Aaron Rodgers throwing for a Packers franchise-record 48 touchdowns.

[27] The Packers defeated the Rams, 32–18,[28] to host the NFC Championship Game for the first time since 2007, where they lost to the eventual Super Bowl champion Tampa Bay Buccaneers, 31–26.

LaFleur was criticized for his decision to kick a field goal down 31-23 instead of trying to tie the game with a touchdown and two-point conversion under league MVP Aaron Rodgers.

Despite the challenges, the Packers emerged victorious, 24–21 with a thrilling last-minute interception of Cardinals quarterback Kyler Murray by cornerback Rasul Douglas, and LaFleur became the winningest head coach through his first 40 career games in NFL history.

With a 37–10 Week 17 victory over the Minnesota Vikings, LaFleur's Packers clinched home-field advantage throughout the NFC playoffs and became the first team in NFL history to win 13 games a season in 3 consecutive years.

In the playoffs, they lost their first game to the San Francisco 49ers, 13–10, giving LaFleur a 2–3 postseason record and no Super Bowl appearances in their three straight 13-win seasons.

The Packers won their next 4 games in a row to get back to a .500 record, setting up a matchup with the Detroit Lions at home with a playoff berth on the line.

[39] The following week, the Packers played the Kansas City Chiefs on Sunday Night Football, winning 27-19 and bringing them back up to a .500 record.