Moore spent the majority of his professional career from 2012 to 2017 as a backup, seeing playing time with the Dallas Cowboys in 2015.

After retiring as a player, Moore served as an offensive coordinator of the Cowboys, Los Angeles Chargers, and Philadelphia Eagles, winning Super Bowl LIX with the latter, prior to being named Saints head coach on February 11, 2025.

His father Tom was the head coach at Prosser High School from 1986 to 2008,[1] winning 21 league titles and four state championships.

[2] According to his mother, Moore "grew fast, and then he didn't grow again" – he was 5 ft 11 in (1.80 m) as a high school sophomore, nearly his adult height.

Moore earned league player of the year honors as well as First-team All-league recognition as a sophomore, junior and senior.

He led Prosser to a 12–1 record in 2006 as a senior and a spot in the state semifinals, where his team lost to the Centralia Tigers and Moore threw two interceptions.

Moore's teammates at Boise State included his younger brother Kirby and childhood friend Cory Yriarte, a center for the Broncos.

As a redshirt freshman in 2008, Moore led the Broncos to an undefeated regular season and the WAC championship while throwing 25 touchdowns and 9 interceptions in 12 games.

He was named to Phil Steele Publications' Second-team All-WAC and also voted to the Football Writers Association of America's freshman All-America team.

Following an opening season win against Georgia in the Chick-fil-A Kickoff Game, Moore was featured on the cover of Sports Illustrated, distributed only in the west.

On November 5, the Broncos defeated UNLV and Moore broke the record to become the FBS leader in career wins for a starting quarterback at 46.

On February 21, 2014, it was announced the Lions would not place a restricted free agent tender offer on Moore, allowing him to explore other NFL options.

Despite not tendering an offer, Lions General Manager Martin Mayhew expressed an interest in bringing Moore back for the 2015 season.

[27] On September 6, 2015, Moore was signed to the Dallas Cowboys' practice squad, reuniting with former Lions offensive coordinator Scott Linehan.

[28] After Tony Romo first fractured his left collarbone, he was promoted to the active roster to serve as Brandon Weeden's backup on September 23.

After Romo suffered a second fracture of the collarbone in a Thanksgiving loss against the Carolina Panthers, Moore was promoted to the active roster on December 2 to serve as Cassel's backup.

On December 19, Moore played in his first career regular season game against the New York Jets, replacing an ineffective Cassel.

The loss against the Jets officially eliminated the Cowboys from playoff contention, which led the organization to decide to use the last two regular season games to audition Moore.

His first career start came the following week against the Buffalo Bills, completing 13-of-31 passes and throwing a third quarter interception to AJ Tarpley as the Cowboys lost 16–6.

[45] On January 30, 2023, Moore was hired by the Los Angeles Chargers as their new offensive coordinator under third-year head coach Brandon Staley.

[48] The Eagles would go on to beat the Kansas City Chiefs in Super Bowl LIX on February 9, 2025, with a score of 40–22.