While in high school, Lojeski played basketball, baseball, and soccer, and also competed in cross country sports.

While at Hawaii, he was selected to the Great Alaska Shootout's All-Tournament Team, and was named the Most Outstanding Player of the Rainbow Classic in 2006.

[5] Lojeski began his pro career in 2007, with the Belgian League club Okapi Aalst.

[8] On July 31, 2013, Lojeski signed a two-year contract with the back-to-back defending EuroLeague champions Olympiacos.

[11] With Olympiacos, he won the 2013 edition of the FIBA Intercontinental Cup, and the Greek League championship in 2015 and 2016.

On February 17, 2019, he won the Greek Cup title after Panathinaikos beat PAOK (79:73) in the big final, held in Heraklion, Crete.

At the end of the season, Matt won another Championship with the Greens (3rd in a row and 38th trophy for Panathinaikos) having 8.7 points, 2.0 rebounds and 1.9 assists in 17.9 minutes per game.

On September 7, 2015, during EuroBasket 2015, he hit a buzzer-beating tip-in against Lithuania, which gave Belgium a 76–74 win.