While representing the senior Greek national team, Printezis was instrumental in Greece's bronze medal run at the 2009 EuroBasket.

In 2009, Printezis signed a three-year contract with an NBA escape clause after the second year, worth €3.6 million net income, with the Spanish ACB League club Unicaja Málaga.

[6] In the EuroLeague's 2011–12 season's Final, Printezis hit a game-winning shot, off an assist from Vassilis Spanoulis, with 0.7 seconds remaining on the game clock, to give Olympiacos the EuroLeague championship, with a victory over the Russian VTB United League club CSKA Moscow.

[13] On June 17, 2022, Printezis officially announced his retirement from playing professional club basketball, after winning the Greek Basket League championship of the 2021–22 season with Olympiacos.

In the summer of 2012, Printezis turned down a one-year contract offer from the Knicks, that reportedly was for slightly more than the minimum NBA salary.

[9] On 16 July 2012, his and Kostas Papanikolaou's draft rights were traded to the Portland Trail Blazers, in a deal that sent Raymond Felton to New York.

[16] On 21 February 2013, the draft rights to Printezis were subsequently traded to the Oklahoma City Thunder, in a deal that sent Eric Maynor to the Portland Trail Blazers.