Wayne is probably best known for his work on the animated series Niko and the Sword of Light, Cannon Busters and Ben 10: Omniverse, and writing and editing comic books for Milestone Media.
When McDuffie co-founded the comic book company Milestone Media, Wayne was hired as an editor on titles such as Icon and Hardware.
Wayne credits his friend Richard Pursel for helping him get his first job writing in television for the animated series Poochini.
Wayne was hired to write several episodes of the animated series Justice League Unlimited and was eventually promoted to story editor.
Continuing his work on animated projects based on popular comic books, he also wrote several episodes of Legion of Super Heroes and The Spectacular Spider-Man.