After achieving success on both The Sopranos and Mad Men, he wrote, directed, and produced the comedy-drama film Are You Here in 2013, published his first novel Heather, the Totality in 2017, and created the anthology drama series The Romanoffs in 2018.

[13][14] Weiner wrote the pilot of Mad Men in 1999 as a spec script while working as a writer on Becker.

[1] The Sopranos creator and executive producer David Chase offered Weiner a job as a writer for the series after being impressed by the script.

Weiner served as showrunner, an executive producer, and head writer of Mad Men throughout its seven seasons.

As the showrunner he had a major role in the writing and directing of each episode, also approving actors, costumes, hairstyles, and props.

Weiner won the Primetime Emmy Award for Outstanding Writing for a Drama Series for the pilot episode, "Smoke Gets in Your Eyes", in 2008, as well as being nominated for "The Wheel" (with Robin Veith).

He also won Primetime Emmys for the same category in 2009, for "Meditations in an Emergency" (shared with Kater Gordon),[18] and in 2010, for "Shut the Door.

[21][22][23] They were nominated for the WGA award for Best Dramatic Series a second time at the February 2009 ceremony for their work on the second season.

[24] Weiner and the writing staff won the WGA Award for Best Drama Series (after being nominated for the third consecutive year) at the February 2010 ceremony for their work on the third season.

[25] Weiner was also twice nominated for the WGA award for episodic drama at the February 2010 ceremony for his work on "The Grown-Ups" (with co-writer Brett Johnson) and "Guy Walks into an Advertising Agency" (with Robin Veith).

One of their four sons, Marten Holden Weiner, played the recurring role of Glen Bishop on Mad Men.

"[30] On November 9, 2017, former Mad Men writer Kater Gordon accused Weiner of making a comment at the office one night to the effect that she owed it to him "to see her naked."