Prince began teaching at University of Illinois Chicago School of Law when the CAN-SPAM Act of 2003 passed, inspiring him to found Unspam and Project Honey Pot, an open source data collection software.

In 2009, he created Cloudflare with Harvard Business School alumnus Michelle Zatlyn and Project Honey Pot co-founder Lee Holloway.

[8] In 1996, Prince graduated from Trinity College with a Bachelor of Arts, majoring in English literature and minoring in computer science.

He co-wrote a paper on the CAN-SPAM Act of 2003 following its passage in the UIC John Marshall Journal of Information Technology & Privacy Law.

[16] The creation of the National Do Not Call Registry through the CAN-SPAM Act inspired Prince to create Unspam, a spam-prevention software for email.

The DHS' email served as the impetus for Cloudflare, a technology company Prince co-founded with Holloway and fellow Harvard Business School graduate Michelle Zatlyn the following year.

[22] Despite maintaining a free speech stance, Prince personally suspended service for the neo-Nazi website The Daily Stormer.

An internal email by Prince and obtained by Gizmodo said that he felt compelled to act after users of The Daily Stormer began boasting that Cloudflare was "one of them".

[23] Prince defended suspending Kiwi Farms' service in September 2022 after the site engaged in a harassment campaign against Twitch streamer Clara Sorrenti in August of that year.

[28] According to Forbes, Prince has a net worth of US$2.3 billion as of March 2023,[update] making him the second wealthiest person in Utah behind Gail Miller.