Matthias Diependaele (born 7 Augustus 1979 in Sint-Niklaas) is a Belgian politician affiliated to the New Flemish Alliance (N-VA) who is the current Minister-President of Flanders, having taken office in 2024.

He additionally serves as the Flemish Minister for Economy, Innovation en Industry, External Affairs, Digitalisation, and Facility Management.

In 2013, Diependaele became the parliamentary leader for the N-VA in the Flemish parliament, succeeding Kris Van Dijck.

[3] After the 2018 local elections, the N-VA formed a new coalition with CD&V and Diependaele was appointed as an alderman tasked with traffic, mobility, public works, spatial planning, submunicipalities and animal welfare.

On 2 October 2019, Diependaele became the Minister for Finance, Budget, Housing and Immovable Heritage in the new Jambon Government.