In 2001 he co-founded with Giovanni D'Aloia the project Kinotek,[3] a seminal VJing and live-media group based in Rome, among the first Italian collectives to use digital tools during their performances.
In 2005 he collaborated with the electronic music composer Maurizio Martusciello in the audiovisual project X-Scape, presented at Mutek Festival in Montreal and IXEM in Venice.
[12][13] In 2012 he designed a visualization of data from the NASA Exoplanet Science Institute as part of a site-specific performance by environmental artist Lita Albuquerque for the Knowledge Festival at the Mount Wilson Observatory in California.
[15] In 2016 Casalegno produces the installation TWINS, inspired by Kinbaku, the Japanese art of bondage: "I like this idea of tying down some sort of freedom in order to induce a heightened state of awareness.
[18] For this Mixed Reality project he collaborated with chef Chintan Pandya, food writer Gail Simmons, electronic musicians dj Spooky and Maurizio Martusciello, and restaurateur Roni Mazumdar.