Mattia de Rossi (14 January 1637 – 2 August 1695) was an Italian architect of the Baroque period, active mainly in Rome and surrounding towns.
Among his works are the facades of the churches of Santa Galla and San Francesco a Ripa (built 1681–1701); finishing touches or reconstruction for Sant'Andrea al Quirinale, Santa Maria in Montesanto, and Santa Croce e San Bonaventura dei Lucchesi; the customs office in Ripa Grande; the Palazzo Muti Papazzurri (attributed, 1660); the tomb monument to Giovanna Garzoni in Santi Luca e Martina; the Mausoleum of Leo X; and the monument to Clement X in St. Peter's Basilica.
This latter funereal monument was designed by de Rossi, but the sculptures were completed by Lazzaro Morelli, Ercole Ferrata and Giuseppe Mazzuoli.
The buildings were commissioned by the Principe Don Angelo Altieri, nephew of Pope Clement X, who had just acquired the surrounding estate.
In 1685 de' Rossi decorated on behalf of Cardinal Raimondo Capizucchi the chapel of San Paolo in the church of Santa Maria in Campitelli.