It is thought it was constructed for the newly married Pompeo Muti Papazzurri and Maria Isabella Massimo.

A print of 1699 shows a large townhouse built around an open cour d'honneur, the court being entered through a triumphal arch at the centre of a Baroque screen linking the two flanking wings.

The screen still remains but has today had rooms built above it, thus completely altering the open appearance of the palazzo to a plain closed façade.

[1] In 1909 the palazzo was heavily restored which has changed de' Rossi's architectural concept of the original design by removing the pediments to the windows and the statuary decorating the roofline.

The gallery, one of the principal reception rooms, has frescos depicting scenes from classical mythology attributed to Giovanni Francesco Grimaldi and Niccolò Berrettoni.