His younger brother Sir Marc Armand Ruffer was an experimental pathologist and bacteriologist.
In 1883, Maurice Ruffer married Coraly Sophie Henriette Straehelin (born 20 March 1862, died 31 Nov 1925).
[3] They had four children: In 1897, Maurice Ruffer acquired the lease on Lyncombe, 1 Crescent Wood Road, Sydenham Hill, London, a banker, of 39 Lombard Street, after the previous owner Henry Gover (c. 1835–1895), a solicitor and educationist had died there in 1895.
[4] In 1923, the lease passed to Francis Ellis, a merchant of 26 & 27 Farringdon Street.
[5][6] In 1955, the Spiritualist Association of Great Britain purchased the lease of the house as their headquarters.