[6] He played an important role in lending arrangements for Argentina, Barbados and Ecuador, and revolving credit lines for Colombia and Mexico.

In September 2018, Claver-Carone was appointed Special Assistant to U.S. President Donald Trump and Senior Director for Western Hemisphere Affairs at the National Security Council.

In this role, Claver-Carone is credited for creating the U.S. government's maximum-pressure campaign against the Maduro regime[8] in Venezuela and for conceptualizing the "América Crece" economic growth strategy and frameworks.

"[18] Despite the controversy, under Claver-Carone's presidency, the IDB successfully optimized its balance sheet to deliver record-breaking financing of $23.4 billion while implementing unprecedented cost savings;[19] more than doubled its net income from 2020-2022;[20] built a private sector coalition to achieve record-breaking co-financing and mobilization;[21] had the biggest single-year gains ever in transparency indicators and stakeholder satisfaction surveys;[22] named the most women to positions of decision-making power ever in the history of the Bank; ensured small countries were represented in the most senior ranks for the first time; earned long-lost bipartisan support from U.S. Congressional leaders;[23] and ended the Bank's deals with China over the last decade.

[25] After the Inter-American Development Bank, Claver-Carone founded a private-equity firm focused on energy and infrastructure investments in the high-growth markets of Latin America and the Caribbean.