Born from the union of Erminio Macario and Julia Dardanelles, after attending the School of Dramatic Art of Piccolo Teatro (Milan) and at the end of a long apprenticeship as an assistant director with Bruno Corbucci has started to film directing, then at the theater, and finally to the television caring for RAI programs on music.

[1] Biographer of his father Erminio Macario for which he wrote the biography titled Macario, a comedian fallen from the moon,[4] that traces the artist's life from birth in an attic of Porta Palazzo in Turin, to the success on the international stage, dedicated in 2004 a specific autobiographical novel inspired by the world of the magazine:Ballerina in a row.

In it is described in detail, around a love story between a young actor and a Nordic dancer, the world of Variety, which he attended as a teenager in the sixties.

As a poet he has participated in several editions of the International Poetry Festival of Genoa and other Rassegne similar both in Italy and abroad, especially in France, his country of choice.

In the album Bestiary love of the group Chantango is inserted a poem by Mauro Macario, Sam, set to music and sung by Gianluigi Cavaliere with recitatives work by the same author.