It is located on the Gawler line, 14.3 kilometres (8.9 mi) north of Adelaide station.

To the west of the station lies the Australian Rail Track Corporation standard gauge line to Crystal Brook.

[2] The $33 million Mawson Interchange project was officially opened in March 2006, complete with approximately 100 carparks, a large bus interchange and a pedestrian overpass connected to the Elder Smith Rd bridge.

[1] Access to platform one for Gawler-bound services is via a pedestrian overpass on the Elder Smith Road bridge.

In addition to the train, Adelaide Metro operates several bus routes via Mawson Interchange: Mawson Lakes station and interchange was featured in the 2022 A24 horror film, Talk to Me.