Maybrat Regency is located in the western part of Papua Island.

It is the provinces's only landlocked regency, and is bordered: At the 2010 Census, the Maybrat Regency comprised eleven districts (distrik), tabulated below with their areas and their populations at the 2010 Census.

[1] The table also includes the locations of the district administrative centres, the number of administrative villages in each district (totaling 259 rural kampung and 1 urban kelurahan), and its post codes.

(c) The area and 2010 Census population of what is now Aifat Timur Selatan District are included in the total figures for Aifat Selatan District, from which it was divided.

(h) The area and 2010 Census population of what is now Ayamaru Utara Timur District are included in the total figures for Ayamaru Utara District, from which it was divided.