Mayflower High School is a comprehensive public high school for more than 300 students in grades 9 through 12 located in Mayflower, Arkansas, United States.

The assumed course of study follows the Smart Core curriculum developed by the Arkansas Department of Education (ADE), which requires students complete at least 22 units prior to graduation.

Students complete regular coursework and exams and may take Advanced Placement (AP) courses and exam with the opportunity to receive college credit.

The Mayflower High School athletic emblem (mascot) is the Eagle with purple and gold serving as the school colors.

The Eagles play within the 3A Region 2 Conference and field varsity teams in football, volleyball, golf (boys/girls), bowling (boys/girls), basketball (boys/girls), cheer, baseball, fastpitch softball, and track and field (boys/girls).