[1][2] Former teachers at Clinton Street High School included Charity A. Boyd, Annie L. Fairs, Margaret E. Gray, Bianca Parker, Sadie M. Kirby, Virginia M. Madison, Katie Smith, Julia M. Spencer, Lettye A. Williams, Martha E. Williams, and Winnie A.

[2] It was named after two people, the first being William H. Mayo the former principal of the Clinton Street High School and founder of the State Normal School for Colored Persons (now Kentucky State University); and the second being Edward Ellsworth Underwood, a local physician, activist, and an organizer of the NAACP chapter in Frankfort.

[3][6] The Tiger Inn Café (active from 1931 to 1963) was located near the school and was a popular hangout for students.

[2] Alumni of Mayo–Underwood School included football player, Kermit E. Williams (1930–2006);[7] and Luska Joseph Twyman (1913–1988), Kentucky state's first African American mayor in 1968.

[9] Many African American Frankfort community members were upset with the decision to remove the school, as it was associated with important local history they wished to share with the younger generations.