Mayo-Kebbi Est (Arabic: مايو كيبي الشرقية) is one of the 23 regions of Chad.

It is composed of the northern areas of the former prefecture of Mayo-Kebbi (sub-prefectures of Bongor, Fianga and Gounou Gaya).

The region's capital is Bongor; other major settlements include Djodo Gassa, Fianga, Gam, Gounou Gaya, Guélengdeng, Hollom Gamé, Katoa, Kéra, Kim, Koyom, Moulkou, Nanguigoto, Tikem and Youé.

[1] The main ethnolinguistic groups are the Bagirmi, Kanuri, Kera, Kim, Kwang, Majera, Marba, Masa, Mbara, Musgum, Musey, Ngeté-Herdé peoples, Tobanga and Tupuri.

[3] The region of Mayo-Kebbi East is divided into four departments: