The college is part of the Mayo Clinic academic medical center and is accredited by the Higher Learning Commission (HLC).

[5][11][12] The Mayo Clinic Alix School of Medicine (MCASOM), established in 1972, offers M.D., M.D.-Ph.D. (jointly with MCGSBS), and M.D.-O.M.S.

[22] The CCaTS program is open to medical students at MCASOM and the University of Puerto Rico School of Medicine.

Competitive awards are available to cover program fees while also providing a stipend and support for research expenses.

is a 6-year joint offering of MCASOM and Mayo Clinic School of Graduate Medical Education in which dentists earn their M.D.

[30] MFMER was established as a department of the University of Minnesota with a $1.5 million donation to offer graduate programs at the Mayo Clinic in Rochester.

[26] These steps led to the university and Mayo Clinic to enter into an affiliation and teaching agreement.

The Mayo Clinic College of Medicine and Science is based in Rochester, Minnesota, with additional campuses in Phoenix and Scottsdale, Arizona, and Jacksonville, Florida.