Mayoworth is an unincorporated place in the southwestern part of Johnson County in north-central Wyoming, United States.

Mayoworth is at the western terminus of Wyoming Highway 191, approximately 12 miles west of the Kaycee exit off Interstate 25 (with U.S. Route 87).

[2] Mayoworth is on the North Fork of the Powder River, which experienced severe flooding in 1992.

[3] The Mayoworth Number Ten clay mine is just to the northwest of town.

[4] Barnum is several miles south of Mayoworth, and Big Trails is the nearest place over the Bighorn range.