Mayslick, originally known as May's Lick) is a census-designated place and unincorporated community in Mason County, Kentucky, United States.

[3] May's Lick was founded in 1788 by six families from Scotch Plains, New Jersey:[5] Abraham, Cornelius, and Isaac Drake were brothers, and John and Mary Shotwell were siblings.

[8] Mays Lick is in southern Mason County, 12 miles (19 km) southwest of downtown Maysville.

U.S. Route 68 runs along the eastern edge of the community, leading north to Maysville and to Ohio, and southwest 54 miles (87 km) to Lexington.

[1] The community is drained by several small streams that flow north to Lees Creek, a north-flowing tributary of the North Fork of the Licking River, which joins the Ohio River at Covington.