Maysville, also known as Mayville, is an unincorporated community within the city of Huntsville, AL in eastern Madison County, Alabama, United States.

Maysville was probably named for the May family, who were early settlers of the area.

[3] The area was once cotton and corn fields, but with the high-tech boom created by NASA Marshall Space Flight Center, and the Missile Defense Agency, the area has transformed into a grouping of subdivisions such as Cooper Estates and Maysville Estates.

A post office operated under the name Maysville from 1850 to 1955.

This Madison County, Alabama state location article is a stub.