Mazenzele originated in the Frankish period as a settlement around an open village fallow.
The forest became famous in the Middle Ages for the quarries that were exploited there from the 12th to the 16th century on the initiative of Affligem Abbey.
The forest covers about 80 hectares and has an undulating relief with its highest point at 80 metres above sea level.
At the heart of the village is the centuries-old St. Peter's Church, built in Romanesque style.
During World War I, the church was severely damaged by German troops.