On the boundary of these countries, the Mbuluzi cuts through the Lebombo Range, before entering the Mozambican plain.
The river passes through the northeastern lowveld of Eswatini, specifically traversing Hlane Royal National Park and Shewula Nature Reserve.
In Eswatini, in the vicinity of the sugar plantations of Mhlume, the river is impounded by the Mnjoli Dam.
The river is augmented by various tributaries before its waters enter Maputo Bay.
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