By mid-1920, Women's Hospital needed more space and moved to a remodeled house on six acres at 1900 Lapeer Street in Flint, opening in June 1923 with 29 rooms.

Margaret McLaren became Superintendent of Women's Hospital in 1924, serving for over 30 years.

After raising $2.5 million from the community in the 1940s, the new 203-bed McLaren General Hospital was dedicated on September 12, 1951, at 401 S. Ballenger Highway in Flint.

[2] The hospital was renamed McLaren Regional Medical Center in 1990 after completing a new patient care tower.

[3] In the following decades, McLaren expanded by acquiring hospitals in Lapeer, Bay City, Mount Clemens, and Lansing, forming the McLaren Health Care Corporation.