[5] This town developed as a trading center for the agricultural county, which had an early economy based on the cultivation of cotton.

Together the highways lead west 32 miles (51 km) to Natchez.

According to the United States Census Bureau, Meadville has a total area of 1.1 square miles (2.9 km2), all land.

As of the 2020 United States census, there were 448 people, 230 households, and 144 families residing in the town.

In 2000, the racial makeup of the town was 82.85% White, 15.41% African American, 0.77% Asian, and 0.96% from two or more races.