[citation needed] The route serves as a quieter, more scenic alternative to the Bass Highway for travelers between Deloraine and Launceston.

[citation needed] The Meander Valley Highway has long been a key road for residents and farmers of northern Tasmania.

The highway was officially designated as B54 in the late 20th century to better integrate it with Tasmania's alphanumeric road numbering system.

[citation needed] Various sections of the Meander Valley Highway have been subject to improvements over the years to enhance safety and traffic flow.

These include resurfacing and shoulder-widening projects in response to increased usage by heavy vehicles, particularly those related to the agricultural and dairy industries in the region.