The Old High School building was built between 1894 and 1896 with a rear wing including a gym added in 1914 to its location on 22-24 Forest Street near Medford Square.

[8] Between 2013 and 2014, Medford High School underwent additional renovation to improve its science labs and reopen its pool.

A separate English Language Learners department includes courses for bringing non-native speakers up to fluency.

Through the math and media and technology departments, computer oriented electives include C++, digital video, and web design.

[12] Medford High School is a member of the Massachusetts Interscholastic Athletic Association in the Greater Boston League.

[13] Medford High School is best known for its boys and girls soccer teams, as well as its men’s ice hockey team Medford High School offers a number of clubs including the Book Club, the National Honor Society, and the MHS Band.

The school's yearbook is assembled by its members and Mustang News recently transitioned from an offline newspaper to an all online format.

[14] Medford High School's underwater robotics team is one of its most successful extra circular activities.