Completed in 1931, the 10-story structure originally provided office space for physicians and dentists, and at the time was considered the "best equipped" medical building in the South.

[7] Following World War I, the James Park House (at the corner of Walnut and Cumberland) was converted into a clinic, in part because of the large number of doctors' offices in its vicinity.

[2] In the late 1920s, prominent physician Herbert Acuff (1886–1951), seeing a necessity for a more modern medical office building, recruited several investors, and purchased the lot at the corner of Main and Locust.

A parking lot and the law firm Hodges, Doughty & Carson separates it from Henley Street to the west, and the Knoxville Post Office lies across Locust to the east.

The entrances along Main and Locust are decorated with terra cotta buttresses, pointed arches, and brass double-doors flanked by transoms with Gothic tracery elements.