It was established in 1995 in Poland and has been published by International Scientific Information based in Melville, New York, U.S.A. since 2002.

It was published in both print and online formats until 2012, at which point the journal became online-only.

Medical Science Monitor is indexed in JCR Clarivate, PubMed, PubMed PMC, EMBASE, and Scopus, which provide abstracts and indexing for publications in established medical journals.

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