It is the lead single, was originally intended as the name of the album, and was promoted as such in numerous interviews and early reviews,[1][2] but the album title was changed shortly after the replacement of producer T Bone Burnett in favor of Dave Matthews Band producer, Mark Batson.
[3][4] Potter has said of the song, "Matt and Scott came up with the music for 'Medicine'—the drum roll and that killer guitar hook—months before I came up with the lyrics or the vocal melody.
I picture my adversary as a young Stevie Nicks, but with long black hair, who shows up, woos everybody and freaks me out, until I realize there is something I can do—then I step up and make my own magic.
WRBC, a Maine-based music magazine said of "Medicine", "The single 'Medicine' represents some of the best elements of Ms. Potter's revamped sound, most notably her songwriting and thumping classic rock guitar lines.
[12] On September 15, 2010, on their official Myspace page, Grace Potter and the Nocturnals announced they were filming "Medicine" as the second music video for the album, for release in December 2010.