Medina first appeared in Lloyd's Register (LR) in 1811 with Kenneday, master, Davy & Co., owners, and trade Exmouth–London.

A gale on 20 October 1820, at Deal drove Medina, Kennedy, master, causing her to lose an anchor.

British ships were then free to sail to India or the Indian Ocean under a license from the EIC.

A report dated Plymouth, 15 January 1822, stated that she had almost completed her repairs and was expected to sail shortly for Bombay.

[10] 1st convict voyage (1823): Captain Robert Brown sailed from Cork on 5 September 1823 and arrived at Sydney on 23 December.

[12] 2nd convict voyage (1825): Captain John Briggs sailed from the Downs on 26 April 1825, and arrived at Hobart on 14 September.

On 23 July, she was pulled off the reef with the assistance of boats and men from HMS Cruizer and Sulphur.

[18] Captain Pace had planned to sail on 30 August, for Batavia, but had to delay his departure to 30 September, due to damage to Medina's keel.