Medway station was originally part of the New York, New Haven and Hartford Railroad, until the line was cut back to Needham Junction in July 1938.

By 1955, ridership on the line was remarkably poor, and only a single round trip per day served the station.

Only two years after the Massachusetts Bay Transportation Authority was formed, service to the station was no longer available.

The Town of Medway decided to not continue funding the train and the line was subsequently cut back to Millis.

Just under a year later, service on the entire line past Needham Junction was discontinued, and has not returned since.