His father was killed when the satrapy rebelled in 484 BCE,[1] and Megabyzus led the forces that recaptured the city, after which the statue of the god Marduk was destroyed to prevent future revolts.
[2] When Xerxes I was assassinated in 465 BCE, he was succeeded by his son Artaxerxes I, but several parts of the Achaemenid empire soon revolted, foremost of which were Bactria and Egypt.
He contacted the Greeks, who were also officially still at war with Persia, and in 460 BCE, Athens sent an expeditionary force of 200 ships and 6000 heavy infantry to support Inarus.
[4] Diodorus has more or less the same story, with more detail; after the attempt at bribery failed, Artaxerxes put Megabyzus and Artabazus in charge of 300,000 men, with instructions to quell the revolt.
[5] Modern estimates, however, place the number of Persian troops at the considerably lower figure of 25,000 men given that it would have been highly impractical to deprive the already strained satrapies of any more man power than that.
The Persians, not wanting to sustain heavy casualties in attacking the Athenians, instead allowed them to depart freely to Cyrene, whence they returned to Athens.
Armies under Usiris of Egypt and the prince Menostanes, a nephew of the king, were sent against him, both forgoing battle for (non-fatal) duels between the generals, and in both cases Megabyzus was victorious.
Some time later, Megabyzus saved Artaxerxes from a lion in a hunt and was subsequently exiled to Cyrtae for violating the royal prerogative to make the first kill, but he returned to Susa by pretending to be a leper and was pardoned.