She is fought most times Zagreus travels through the first area of the game, Tartarus, and can be found at the House of Hades.

[2] Kasavin touched upon the possible polyamorous relationship between Megaera, Zagreus, and Thanatos, noting that it was something that developed over time instead of being present from the beginning.

Megaera was named one of the 10 best characters of 2020 by Game Informer writer Joe Juba, feeling that Zagreus' repeated battles with Megaera creates a lasting impact, particularly thanks to her "wry and competitive personality" that improves the dialogue for Juba.

[4] Destructoid writer Noelle Warner enjoyed her voice acting, noting that it made her swoon and calling it the standout performance of the game.

She felt that the fight feels too much like a tutorial, and that her skillset lacks the diversity of other bosses, including her sisters.

[8] Kotaku writers Nathan Grayson and Ari Notis discussed Megaera and Zagreus' relationship, with Grayson enjoying how she tries to keep Zagreus at arm's length to make it easier for her to view him as an opponent she has to stop instead of a "weird sorta-friend.

The Mary Sue writer Briana Lawrence was shocked to discover that polyamory between the three was possible, enjoying watching Zagreus work out the issues he has with them over him trying to leave.

[10] Wired writer Gabriel Aikins also discussed the polyamory between the three, as well as the matter of kink and consent in their relationship.

[11] Wired writer Autumn Wright Megaera's androgynous appearance represented a "subvers[ion] to classical tradition" in Ancient Greek culture, and that this androgyny would be considered demeaning to Zagreus.