Megalictis (meaning "great weasel") is an extinct genus of large predatory mustelids that existed in North America during the "cat gap" from the Late Arikareean (Ar4) in the Miocene epoch.

[2] Specimens of M. ferox have been found at ten sites in South Dakota, Nebraska and Wyoming, dated to the Harrisonian period - from 24.8 to 20.6 million years ago.

[6] However, later studies identified significant morphological variation in the joints of the forearms, which would not be consistent with sexual dimorphism.

[8] Recovered skulls of Megalictis ferox had similar condylobasal lengths to small modern jaguars, ranging from 189.5 to 241.1 mm (7.46 to 9.49 in) in length, and were almost as wide in mastoid width as those of some black bears, ranging from 106.1 to 136 mm (4.18 to 5.35 in) wide.

The enlarged anterior edge of the cornoid process confers a wide gape relative to its short rostral length, suggesting Megalictis possessed a powerful bite force; together with blunt, stout postcanine teeth, Megalictis was well equipped to engage in osteophagy, similar to modern hyenas and wolverines.