Zodiolestes is a genus of mustelids, now extinct, which existed during the Miocene period.

The genus was first described in 1942, by E. S. Riggs, who identified the sister genus Promartes at the same time, and assigned to the family Procyonidae.

In 1998 it was assigned to the subfamily Oligobuninae of the family Mustelidae.

[1] Z. daimonelixensis showed digging adaptations, and one fossil was found curled up in the "corkscrew" burrow of the Miocene beaver, Palaeocastor.

[3] This situation was analogous to the modern day prairie dog (genus Cynomys) and its predator the black-footed ferret (Mustela nigripes).