She predominantly appears in Telugu and Kannada television series, and became known for the serial Sasirekha Parinayam (2013 - 2016) as Sasi B.Tech and Devayani which premiered on the Star Maa channel.

Her big breakthrough was with the Telugu hit series Sasirekha Parinayam which screened on Star Maa from 2013 to 2016.

She also acted in the feature film Idhi Ma Prema Katha[3] opposite Anchor Ravi, which received mixed reviews.

Later that year, Meghana started a new Zee Telugu series Kalyana Vaibhogam in which she is portraying the dual role of Manga and Nithya.

Around the time, She was signed to play a lead role in her third Telugu Soap Opera titled, Raktha Sambandham.