Megistostegium nodulosum grows as a tree up to 8 metres (30 ft) tall.

[3] Megistostegium nodulosum is found at numerous locations throughout southern Madagascar, including in protected areas.

[2] Megistostegium nodulosum has been assessed as least concern on the IUCN Red List.

Megistostegium nodulosum is present in a number of protected areas, including Andohahela National Park and Cap Sainte-Marie Special Reserve.

The bark, leaves and twigs are locally used to treat conditions including eye ailments and stomach aches.