Mehmet Ali Vrioni was an Albanian politician and the vice president of the League of Prizren.

It was founded in Istanbul in 1877, with the view of obtaining some autonomy for the Albanians in the Ottoman Empire.

[3][4] In 1879 he and Abdyl Frashëri left Preveza,[5] and traveled to Paris, Rome, Vienna and Berlin to seek support for the Albanian cause and submit a memorandum of Albanian demands to the Great Powers.

[6][7] This was the most important effort to promote the rights of the Albanian nation during this period.

His third wife was a Circassian from Tuapse and her sister Behixhe Hamza is the mother of Mufid Libohova.